Dr. Ajay Amit
Assistant Professor
Work Experience
As an Assistant Professor in the Department of Forensic Science, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G) since 2019 till date. As a Post-doc with the University of Toronto—2018-2019. Assistant Professor (Ad-hoc)— 2016-2017
Area of Specialization
Host-parasite interaction, cytokine biology, Parasitology, Immunology, Molecular Biology, drug-induced Immunomodulation
Projects & Patents
In-vitro analysis of effect of Cannabidiol (CBD) and Delta-9-tetrahydrocannabinol (THC) on macrophage mediated pathogenesis of Leishmania donovani.
Education
Ph.D. in Biotechnology, Calcutta University, West Bengal, 2018 M.Sc. in Biotechnology, Amity University, Noida, Uttar Pradesh, 2006
Achievments/Awards/Honors
#Cleared CSIR- UGC JRF 2010. #successfully elucidated the vaccine potential of Leishmania donovani protein disulfide isomerase (LdPDI). #h-index-13. #i10-index-16.
Publications
1. Yadav, M., Uikey, B. N., Rathore, S. S., Gupta, P., Kashyap, D., Kumar, C., ... & Amit, A. (2023). Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment. Frontiers in Oncology, 13, 1235711. 2. Mondal, D., Shinde, S., Paul, S., Thakur, S., Velu, G. S. K., Tiwari, A. K., ... & Shukla, D. (2023). Diagnostic significance of dysregulated miRNAs in T-cell malignancies and their metabolic roles. Frontiers in Oncology, 13, 1230273. 3. Soni, V. K., Mehta, A., Ratre, Y. K., Tiwari, A. K., Amit, A., Singh, R. P., ... & Vishvakarma, N. K. (2020). Curcumin, a traditional spice component, can hold the promise against COVID-19?. European Journal of Pharmacology, 886, 173551. 4. Suman, S. S., Kumar, A., Singh, A. K., Amit, A., Topno, R. K., Pandey, K., ... & Bimal, S. (2021). Dendritic cell engineered cTXN as new vaccine prospect against L. donovani. Cytokine, 145, 155208. 5. Singh, AK., Das, VNR., Amit, A…..Bimal, S. Cytokines and chemokines diffrentialy regulate innate immune cell trafficking during post kala-azar dermal leishmaniasis. Journal of cellular biochemistry 119 (9), 7406-7418, 2018(IF: 3.446) 6. Suman, SS., Amit, A,……….Ali, V. Cytosolic trypaerdoxin of Leishmania donovani modulates host immune response in Visceral Leishmaniasis. Cytokine 108, 1-8, 2018. (IF 2.940) 7. Kumar, A., Dikhit, M. R., Amit, A…Bimal., S. Immunomodulation induced through ornithine decarboxylase DNA immunization in Balb/c mice infected with Leishmania donovani. Molecular immunology 97, 33-44, 2018. (IF: 3.375) 8. Dikhit, M. R., Mahantesh, V., Kumar, A., Amit, A., Dehury, B., Ansari, M., ... & Das, P. Mining the proteome of Leishmania donovani for the development of novel MHC class I restricted epitope for the control of visceral leishmaniasis. Journal of Cellular Biochemistry. 119 (1), 378-391, 2018 (IF: 3.446) 9. Dikhit, M. R., Amit, A……Bimal, S. Vaccine potential of HLA-A2 epitopes from Leishmania cysteine protease type III (CPC). Parasite immunology 39 (9), e12451, 2017. (IF-2.836) 10. Chaudhary, R., Amit, A.,…..Bimal, S. A New vaccine strategy of dendritic cell presented kinetoplastid membrane (KMP-11) as immunogen for control against experimental Visceral Leishmaniasis. Modern research in inflammation, 6 (03), 15, 2017. (IF-0.6) 11. Chaudhary, R., Amit, A.,…..Bimal, S. A New vaccine strategy of dendritic cell presented kinetoplastid membrane (KMP-11) as immunogen for control against experimental Visceral Leishmaniasis. Modern research in inflammation, 6 (03), 15, 2017. (IF-0.6) 12. Mahantesh, V., Amit, A., Dikhit, M. R., Singh, A. K., Venkateshwaran, T., Das, V. N. R., ... & Bimal, S. (2017). Immuno-informatics based approaches to identify CD8+ T cell epitopes within the Leishmania donovani 3-ectonucleotidase in cured visceral leishmaniasis subjects. Microbes and Infection.(IF- 2.291) 13. Vijayamahantesh, Amit A, Dikhit MR, Mishra A, Singh AK, Das VN, Das P, Bimal S.Adenosine generated by ectonucleotidases modulates the host immune system during visceral leishmaniasis. Cytokine. 2017 Jan 9;91:170-179. doi:10.1016/j.cyto.2017.01.001. [Epub ahead of print] PubMed PMID: 28082236. (IF- 2.940) 14. Amit A, Vijayamahantesh, Dikhit MR, Singh AK, Kumar V, Suman SS, Singh A, Kumar A, Thakur AK, Das VR, Das P, Bimal S. Immunization with Leishmania donovani protein disulfide isomerase DNA construct induces Th1 and Th17 dependent immune response and protection against experimental visceral leishmaniasis in Balb/c mice. Mol Immunol. 2017 Feb;82:104-113. doi: 10.1016/j.molimm.2016.12.022. PubMed PMID: 28064069. (IF- 3.375) 15. Dikhit MR, Ansari MY, Vijaymahantesh, Kalyani, Mansuri R, Sahoo BR, Dehury B, Amit A, Topno RK, Sahoo GC, Ali V, Bimal S, Das P. Computational prediction and analysis of potential antigenic CTL epitopes in Zika virus: A first step towards vaccine development.Infect Genet Evol. 2016 Nov;45:187-197. doi:10.1016/j.meegid.2016.08.037. PubMed PMID: 27590716. (IF- 2.591) 16. Vijayamahantesh, Amit A, Dikhit MR, Pandey RK, Singh K, Mishra R, Das VN, Das P, Bimal S. Elevated Serum ADA Activity as a Marker for Diagnosis and Prognosis of Visceral Leishmaniasis and Post Kala-Azar Dermal Leishmaniasis in Indian Patients. PLoS One. 2016 May 17;11(5):e0154117. doi:10.1371/journal.pone.0154117. PubMed PMID: 27186641; PubMed Central PMCID:PMC4871472. (IF- 3.057) 17. Vijayamahantesh, Amit A, Kumar S, Dikhit MR, Jha PK, Singh AK, Sinha KK,Pandey K, Das VN, Das P, Bimal S. Up regulation of A2B adenosine receptor on monocytes are crucially required for immune pathogenicity in Indian patients exposed to Leishmania donovani. Cytokine. 2016 Mar;79:38-44. doi:10.1016/j.cyto.2015.12.016. PubMed PMID: 26748211. (IF- 2.940) 18. Amit A, Dikhit MR, Mahantesh V, Chaudhary R, Singh AK, Singh A, Singh SK, Das VN, Pandey K, Ali V, Narayan S, Sahoo GC, Das P, Bimal S. Immunomodulation mediated through Leishmania donovani protein disulfide isomerase by eliciting CD8+ T- cell in cured visceral leishmaniasis subjects and identification of its possible HLA class-1 restricted T-cell epitopes. J Biomol Struct Dyn. 2017 Jan;35(1):128-140. doi: 10.1080/07391102.2015.1134349. PubMed PMID: 26727289. (IF- 2.3) 19. Dikhit MR, Kumar S, Vijaymahantesh, Sahoo BR, Mansuri R, Amit A, Yousuf Ansari M, Sahoo GC, Bimal S, Das P. Computational elucidation of potential antigenic CTL epitopes in Ebola virus. Infect Genet Evol. 2015 Dec;36:369-75. doi: 10.1016/j.meegid.2015.10.012. PubMed PMID: 26462623. (IF- 2.591) 20. Yadav A, Amit A, Chaudhary R, Chandel AS, Mahantesh V, Suman SS, Singh SK, Dikhit MR, Ali V, Rabidas V, Pandey K, Kumar A, Das P, Bimal S. Leishmania donovani: impairment of the cellular immune response against recombinant ornithine decarboxylase protein as a possible evasion strategy of Leishmania in visceral leishmaniasis. Int J Parasitol. 2015 Jan;45(1):33-42. doi:10.1016/j.ijpara.2014.08.013. PubMed PMID: 25449949. (IF- 4.242) 21. Das P, Amit A, Singh SK, Chaudhary R, Dikhit MR, Yadav A, Pandey K, Das VN, Sundram S, Das P, Bimal S. Leishmania donovani phosphoproteins pp41 and pp29 re- establishes host protective immune response in visceral leishmaniasis. Parasitol Int. 2015 Feb;64(1):18-25. doi: 10.1016/j.parint.2014.08.004. PubMed PMID: 25224164. (IF- 1.860) 22. Amit A, Chaudhary R, Yadav A, Suman SS, Narayan S, Das VN, Pandey K, Singh SK, Singh BK, Ali V, Das P, Bimal S. Evaluation of Leishmania donovani disulfide isomerase as a potential target of cellular immunity against visceral leishmaniasis. Cell Immunol. 2014 May-Jun;289(1-2):76-85. doi:10.1016/j.cellimm.2014.03.011. PubMed PMID: 24732062. (IF- 2.399) 23. Chaudhary R, Amit A, Yadav A, Singh A, Kumar V, Singh SK, Narayan S, Rabidas V, Pandey K, Kumar A, Das P, Bimal S. Immunomodulation in human dendritic cells leads to induction of interferon-gamma production by Leishmania donovani derived KMP-11 antigen via activation of NF-κB in Indian kala-azar patients. Biomed ResInt. 2014;2014:947606. doi: 10.1155/2014/947606. PubMed PMID: 24587999; PubMed Central PMID: PMC3919100. (IF- 2.134) 24. Chaudhary R , Yadav A, Amit A, Singh SK, Narayan S….. Bimal S. Leishmania donovani: Evidence for the role of Kinetoplastid Membrane Protein-11 in cellular immunity and anti-leishmanial macrophage function in human Visceral Leishmaniasis. International Journal of Advanced Research (2013), Volume 1, Issue 7, 149-157.