Dr. Rohit Seth

Associate Professor

कार्य अनुभव

(2011 – Present), Associate Professor of Zoology Department, Guru Ghasidas Viswavidyalaya, Bilaspur (CG), INDIA. (2006 – 2011), Instructor and Postdoctoral Associate, College of Medicine, Florida State University (FSU) Tallahassee, FL, USA. (2003 – 2006) Postdoctoral Fellow at Department of Medicine, Division of Nephrology, University of Arkansas for Medical Sciences, Little Rock, AR.

विशेषज्ञता का क्षेत्र

Cancer Biology
Neuroscience
Obesity Research

परियोजनाएं और पेटेंट

1. “Neurobiology of obesity regulation and therapeutic interventions”. Leptin inhibits orexigenic pathways in the CNS and is a powerful appetite suppressant; mutations in genes coding for Leptin or Leptin receptors produce morbid obesity. However, nearly all obese individuals exhibit Leptin resistance. Thus, it is not surprising that early human trials of Leptin administration failed to yield impressive weight loss. However, Leptin treatment sustains normal energy expenditure in subjects that have lost weight by caloric restriction. This observation suggests that weight loss can restore Leptin responsiveness. This project is funded by the SERB (Department of Science and Technology, Govt. of India) to Rohit Seth (2018). 2. “Role of Serum Catalytic Iron, 1-25- Dihydroxy Vitamin D3 and withanolides on autophagy and apoptosis in renal tubular epithelial cells exposed to Iohexol”. This is a consultancy project funded by Dr. Chandrasekar Annamalai, Senior Nephrologist, Apollo Hospital, Bilaspur (CG). 3. “Neuronal Death & Survival: The Treatment of Traumatic Brain Injury”. Neuronal injury and death appears to be a trigger for stem cell proliferation and adult neurogenesis. We are exploring ways to promote neuronal survival after traumatic brain injury, induce neurogenesis, and improve behavioral outcomes. This project was funded by National Institute of Health (2010-11). 4. Central neural control of energy balance, feeding behavior and cardiovascular functions. We studied mechanisms by which reduced energy consumption produces marked reductions in blood pressure and sympathetic activity. For this study we used chronically instrumented rats to assess cardiovascular status while manipulating caloric intake. CNS lesions and microinjection strategies were employed to evaluate specific neuroanatomic and neurochemical substrates which modulate blood pressure during negative energy balance. This project was funded by National Institute of Health (NIH) and research support from College of Medicine, Florida State University (2006-2010). 5. Signal transduction in renal tubular epithelial cells in relation to cell death and cell survival pathways in caspase –3 knockouts. I worked as a co-investigator in this project aimed to address the role of caspase in cisplatin induced acute renal failure. This project was supported by National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), National Institutes of Health and an American Heart Association (Affiliated), (2003-2006). 6. p53 mediated caspase-2-activation in mitochondrial release of apoptosis inducing factor and its role in renal tubular epithelial cell injury. Aim of this project was to address the role of apoptosis inducing factor in cisplatin induced renal tubular epithelial cell injury. This project was supported by National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), National Institutes of Health and an American Heart Association (Affiliated), (2003-2006). 7. USDA (Indo-US fellowship), research grant FG-IN- (IN-ARS-866) to work on project: "Molecular biology of neuroendocrine system of poultry birds" (1999).

शिक्षा

Ph.D.

उपलब्धियां/पुरस्कार/सम्मान

1. Union for International Cancer Control technical fellowship (UICC-TF/17/554101) to conduct joint research at University of Toledo, Toledo, OH (December 8, 2017 – January 07, 2018) 2. Best Poster Presentation at 4th meeting of Association of Scientists of Indian Origin in America. January 15-17, 2011. Suwanee, GA, USA. 3. Travel grant from American Society of Nephrology to attend 38th Annual Meeting of American Society of Nephrology, Philadelphia, Pennsylvania. USA November 8th 2005. 4. DAAD fellowship, German academic exchange services (2001). Availing this fellowship I worked at Institute for Animal Science and Animal Behavior, Mariensee, Neustadt, Germany. 5. Best Oral Presentations at 21st Symposium of Society for Reproduction Biology and Comparative Endocrinology meeting, Banaras Hindu University, Varanasi UP (2003). 6. Best Oral Presentations at 19th Symposium of Society for Reproduction Biology and Comparative Endocrinology meeting (2001), Bhartidasan University, Baroda, Gujarat, INDIA.

प्रकाशनों

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